Suramin

SKU: orb1982121

Description

Suramin is a multifunctional research compound that acts as a dual inhibitor of SARS-CoV-2 RdRp and host PTPases. It is utilized in antiviral, anticancer, and antiparasitic studies, with applications in both in vitro enzymatic assays and in vivo angiogenesis research models.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 145-63-1
• MW: 1297.28
• Purity: 99.80% (May vary between batches)
• Formula: C₅₁H₄₀N₆O₂₃S₆
• SMILES: O=C(NC1=CC=CC(=C1)C(=O)NC2=CC(=CC=C2C)C(=O)NC3=CC=C(C4=CC(=CC(=C34)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC5=CC=CC(=C5)C(=O)NC6=CC(=CC=C6C)C(=O)NC7=CC=C(C8=CC(=CC(=C78)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O
• Target: Topoisomerase,Reverse Transcriptase,DNA/RNA Synthesis,SARS-CoV,Phosphatase,Apoptosis,Sirtuin,Parasite

Bioactivity

• Target IC50:
  SIRT2:1.15 μM|SIRT5:22 μM|SIRT1:297 nM|Topo II:5 μM
• In Vivo:
  Rats were intraperitoneally injected with 50 mg/kg Suramin once a week for 4 weeks, and the results showed that Suramin could slightly promote rat adipogenesis in vivo.
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• In Vitro:
  Low concentrations of 35 μM (50 μg/mL) and 70 μM (100 μg/mL) Suramin were not cytotoxic to prefascial adipocytes. However, high concentrations of 105 μM (150 μg/mL) and 140 μM (200 μg/mL) showed cytotoxic effects by reducing cell viability. Suramin (0-140 μM) stimulated and promoted lipogenic differentiation of FSCs in a time - and dose-dependent manner. Suramin activates Nrf2 and correspondingly inhibits the activated B cell (NF-κB) nuclear factor kappa light chain enhancer and mitogen-activated protein kinase (MAPK) pathway, thereby reducing IL-1β-stimulated chondrocyte inflammation and ECM degeneration. Suramin repolarizes M1 macrophages to M2 phenotype, further reducing apoptosis of chondrocytes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

5361