Sultopride hydrochloride

SKU: orb1300005

Description

Sultopride hydrochloride is a selective antagonist of dopamine D2 and D3 receptors. This compound is utilized in neuroscience research to study dopaminergic pathways and receptor function in both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 23694-17-9
• MW: 390.93
• Purity: 98.00% (May vary between batches)
• Formula: C₁₇H₂₇ClN₂O₄S
• SMILES: Cl.CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)CC
• Target: Dopamine Receptor
• Solubility: DMSO:50 mg/mL (127.9 mM)

Bioactivity

• In Vivo:
  Sultopride and sulpiride are both chemically similar benzamide derivatives and selective antagonists of dopamine D2 receptors. However, these drugs differ in clinical properties. We compared the effects of sultopride and sulpiride on dopamine turnover in rats following the administration of these drugs alone or in combination with apomorphine. The administration of sultopride or sulpiride markedly accelerated dopamine turnover in the rat brain. The increase in the level of dopamine metabolites in the striatum was more marked in the sultopride-treated rats. Sulpiride affected the limbic dopamine receptors preferentially, whereas sultopride affected the striatal and the limbic dopamine receptors equally. A low dose of apomorphine induced a reduction in the concentration of dopamine metabolites in the striatum and the nucleus accumbens by approximately 55%, but not in the medial prefrontal cortex. Sultopride was more effective in preventing an apomorphine-induced reduction in dopamine metabolite levels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

receptor, Sultopride, Sultopride hydrochloride, Sultopride Hydrochloride, striatum, DopamineReceptor, Dopamine, Dopamine Receptor, DOPAC, dopamine, inhibit, LIN1418, LIN-1418, LIN1418 Hydrochloride, LIN-1418 hydrochloride, LIN-1418 Hydrochloride, LIN 1418, LIN 1418 Hydrochloride, levels, Inhibitor, HVA

Compound Identifiers

PubChem CID

3082221