Sulfoxaflor

SKU: orb1306808

Description

Sulfoxaflor is a systemic insecticide and nicotinic acetylcholine receptor (nAChR) agonist targeting pests like aphids and planthoppers. Research applications include its investigation in neurotoxicology and its effects on insect nervous systems, as well as studies on its potential impact on lymphocytes in vitro.

Research Area

Neuroscience

Key Properties

• CAS Number: 946578-00-3
• MW: 277.27
• Purity: 99.98% (May vary between batches)
• Formula: C₁₀H₁₀F₃N₃OS
• SMILES: C(S(=NC#N)(C)=O)(C)C=1C=CC(C(F)(F)F)=NC1
• Target: AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.21 mM);DMSO:55 mg/mL (198.36 mM)

Bioactivity

• In Vivo:
  METHODS: Sulfoxaflor (GF 2032) (25, 100, and 500 mg/kg, gavage, 4 weeks) was administered to rats and the relative testicular mass, testosterone, FSH, LH, MDA, and GPx levels, sperm motility, sperm morphology, sperm DNA damage, and histopathological changes in the testis, epididymis, and seminal vesicle were examined. RESULTS Sulfoxaflor exposure resulted in an increase in FSH, LH, MDA, and GPx levels in sperm, as well as the percentage of dead and abnormal sperm and DNA damage in rat sperm.
• In Vitro:
  METHODS: Blood lymphocytes were treated with Sulfoxaflor (GF 2032) (10 µg/mL, 20 µg/mL, 40 µg/mL), and single cell gel electrophoresis (comet electrophoresis), cytokinesis block micronucleus assay (MN assay), flow cytometry, and catalase (CAT) enzyme activity measurement were used to determine genotoxicity, apoptotic effects, and oxidative damage potential, respectively. RESULTS CPBI values ​​and the number of viable cells decreased; the number of late apoptotic and necrotic cells, micronucleus frequency, and comet assay parameters (GDI and DCP) increased; an increase in CAT enzyme levels was observed at 10 and 20 µg/mL concentrations, and CAT enzyme activity was inhibited at 40 µg/mL.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GF 2032, GF 2372, GF2032, GF-2032, GF2372, GF-2372, insecticide, median, nAChR, nAChR1, nAChR2, Nicotinic acetylcholine receptors, inhibit, Inhibitor, dorsal, Sulfoxaflor, Sulfoximine, XDE208, XDE-208, XDE 208, unpaired

Compound Identifiers

PubChem CID

16723172