Sulfinpyrazone

SKU: orb1310619

Description

Sulfinpyrazone

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 57-96-5
• MW: 404.48
• Purity: 98.09% (May vary between batches)
• Formula: C₂₃H₂₀N₂O₃S
• SMILES: O=C1N(N(C(=O)C1CCS(=O)C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4
• Target: COX,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.94 mM);DMSO:40 mg/mL (98.89 mM);Ethanol:64 mg/mL (158.23 mM)

Bioactivity

• In Vivo:
  Sulfinpyrazone exerts significant electrophysiologic actions under various experimental conditions. It raises the ventricular fibrillation threshold as well as the mid diastolic threshold and prolongs the effective refractory period. In the acutely ischemic heart, it attenuates the effect of coronary occlusion on the ventricular fibrillation threshold but has no effect after reperfusion. A protective influence of the drug is also evident during sympathetic humoral stimulation with norepinephrine. The antifibrillatory effect of sulfinpyrazone is additive to the changes elicited by beta adrenergic blockade with practolol or cardiac membrane stabilization with lidocaine.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX, antithrombotic, arthritis, (+/-)-Sulfinpyrazone, intermittent, NSC 75925, inhibit, oral, NSC75925, NSC-75925, gouty, G28315, G-28315, G 28315, Inhibitor, platelet, Sulfinpyrazone, uricosuric

Compound Identifiers

PubChem CID

5342