Sulfadoxine

SKU: orb1225536

Description

Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.(In Vitro):Sulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2447-57-6
• MW: 310.33
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₄N₄O₄S
• SMILES: O=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC)=C2OC)=O
• Target: Autophagy
• Solubility: Water: 62 mg/mL (199.78 mM)

Bioactivity

• In Vitro:
  Sulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i. e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro 4-4393

Quick Database Links

Gene Symbol

Autophagy