Sulbutiamine

SKU: orb1220594

Description

Sulbutiamine is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.(In Vitro):Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3286-46-2
• MW: 702.89
• Purity: >98% (HPLC)
• Formula: C₃₂H₄₆N₈O₆S₂
• SMILES: CC(C)C(=O)OCC\C(SS\C(CCOC(=O)C(C)C)=C(\C)N(Cc1cnc(C)nc1N)C=O)=C(/C)N(Cc1cnc(C)nc1N)C=O
• Target: Others
• Solubility: DMSO:75 mg/mL (106.70 mM)

Bioactivity

• In Vitro:
  Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bisibuthiamine

Quick Database Links

Gene Symbol

Others