Sucralfate

SKU: orb1308927

Description

Sucralfate is a cytoprotective, sucrose-based aluminum complex used in research for treating active duodenal ulcers. It is applied in gastroenterology studies to investigate mucosal defense mechanisms, with utility in both in vivo ulcer models and in vitro assays examining its barrier-forming and growth factor-binding properties.

Research Area

Cardiovascular Research, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 54182-58-0
• MW: 2086.75
• Formula: C₁₂H₅₄Al₁₆O₇₅S₈
• SMILES: O([C@@]1(COS([O-][Al+3]2([OH-])[OH-][Al+3]([OH-])([OH-])[OH-]2)(=O)=O)[C@@H](OS([O-][Al+3]3([OH-])[OH-][Al+3]([OH-])([OH-])[OH-]3)(=O)=O)[C@H](OS([O-][Al+3]4([OH-])[OH-][Al+3]([OH-])([OH-])[OH-]4)(=O)=O)[C@@H](COS([O-][Al+3]5([OH-])[OH-][Al+3]([OH-])([OH-])[OH-]5)(=O)=O)O1)[C@@H]6[C@H](OS([O-][Al+3]7([OH-])[OH-][Al+3]([OH-])([OH-])[OH-]7)(=O)=O)[C@@H](OS([O-][Al+3]8([OH-])[OH-][Al+3]([OH-])([OH-])[OH-]8)(=O)=O)[C@H](OS([O-][Al+3]9([OH-])[OH-][Al+3]([OH-])([OH-])[OH-]9)(=O)=O)[C@@H](COS([O-][Al+3]%10([OH-])[OH-][Al+3]([OH-])([OH-])[OH-]%10)(=O)=O)O6
• Target: FGFR,Antibacterial,Prostaglandin Receptor
• Solubility: H2O:0.4 mg/mL (0.19 mM);DMSO:20.87 mg/mL (10 mM)

Bioactivity

• In Vivo:
  The protective effects of sucralfate against ARC(acute radiation colitis) may be partially due to the supression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region.
• In Vitro:
  Sucralfate may inhibit intestinal epithelial motility by sterically interfering with adhesion to collagen I. It protects RGMl cells from acid- and pepsin-induced damage.
• Cell Research:
  Sucralfate is dissolved or suspended in culture medium containing 20% FBS. Cells are incubated with the agent at 37°C under 5% CO2, in air for 0.5-4 h. In some cases, cells are treated with 10-5mol/L indomethacin for 4h before the addition of the agent to determine whether or not intracellular prostaglandins are involved in the protective mechanisms of sucralfate. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pepsin, PGF, Prostaglandin Receptor, ProstaglandinReceptor, Sucrose octasulfate-aluminum complex, Sucrose octasulfate–aluminum complex, Sucralfate, FGF2, Fibrinogen chain, inhibit, Inhibitor, Bacterial

Quick Database Links

Gene Symbol

FGFR,Antibacterial,Prostaglandin Receptor