Succinobucol

SKU: orb1302985

Description

Succinobucol

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 216167-82-7
• MW: 616.91
• Purity: 98.80%
• Formula: C₃₅H₅₂O₅S₂
• SMILES: CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(OC(=O)CCC(O)=O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C
• Target: Reactive Oxygen Species,ROS,Antioxidant
• Solubility: DMSO:45 mg/mL (72.94 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.24 mM)

Bioactivity

• In Vivo:
  In lung metastatic breast cancer mice, Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules. In rats, Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP.
• In Vitro:
  In rabbit whole blood, Succinobucol (10, 50, 100 μM) causes a dose-dependent reduction in collagen-induced platelet aggregation. Succinobucol (10, 100 μM) significantly lowers the relaxation to X/XO.
• Cell Research:
  In the metastatic 4T1 breast cancer cells, Succinobucol, SCB and the PCD polymer (equivalent concentration to SCB) are respectively added to each well with SCB concentrations ranging from 4 ng/mL to 40 μg/mL.
• Animal Research:
  Mice, injected 4T1-luc cells, are treated with Succinobucol (40 mg/kg) by tail injection every three days.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antioxidant, AGI 1067, AGI1067, AGI-1067, Inhibitor, inhibit, Succinobucol, Probucol, Probucol monosuccinate, Probucol Monosuccinate, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

216325