Suberosin

SKU: orb1301483

Description

Suberosin

Research Area

Signal Transduction

Key Properties

• CAS Number: 581-31-7
• MW: 244.29
• Purity: 99.26%
• Formula: C₁₅H₁₆O₃
• SMILES: COc1cc2oc(=O)ccc2cc1CC=C(C)C
• Target: NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.19 mM);DMSO:45 mg/mL (184.21 mM)

Bioactivity

• In Vitro:
  Suberosin suppressed PHA-induced PBMC proliferation and arrested cell cycle progression fro the G1 transition to the S phase. Suberosin suppressed, in activated PBMC, transcripts of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and cyclins D3, E, A, and B. DNA binding activity and nuclear translocation of NF-AT and NF-kappaB induced by PHA were blocked by suberosin. Suberosin decrease the rise in intracellular Ca2+ concentration [Ca2+ i) in PBMC stimulated with PHA. Suberosin did not affect phosphorylation of p38 and JNK but did reduce activation of ERK in PHA-treated PBMC. Pharmacological inhibitors of NF-kappaB, NF-AT, and ERK decreased expression of mRNA fo the cyclins, IL-2, and IFN-gamma and cell proliferation in PBMC activated by PHA.
• Cell Research:
  Proliferation of PBMC in culture was measured by uptake of 3H-thymidine; production of cytokines and cyclins by Western blotting and RT-PCR. Transcription factors NF-AT and NF-kappaB were assayed by immunocytochemistry and EMSA

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, NF-κB, NFκB, NF-kB, NFkB, Nuclear factor-kappaB, Nuclear factor-κB, inhibit, Suberosin

Compound Identifiers

PubChem CID

68486