SU5204

SKU: orb1305928

Description

SU5204 is a small molecule VEGFR2 (FLK-1) inhibitor with an IC50 of 4 μM, and it also inhibits HER2 (IC50 = 51.5 μM). This SU5025 analogue is a useful research tool for studying angiogenesis and oncology in both cellular and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 186611-11-0
• MW: 265.31
• Purity: 99.5%
• Formula: C₁₇H₁₅NO₂
• SMILES: CCOc1ccccc1C=C1C(=O)Nc2ccccc12
• Target: EGFR,VEGFR,HER
• Solubility: DMSO:27.5 mg/mL (103.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.54 mM)

Bioactivity

• Target IC50:
  HER2:51.5 μM|VEGFR2:4 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one, inhibit, EGFR, ErbB-1, Epidermal growth factor receptor, Inhibitor, HER1, HER2, SU 5204, SU5204, SU-5204, VEGFR, VEGFR2, Vascular endothelial growth factor receptor

Compound Identifiers

PubChem CID

2803108