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SU4312

SKU: orb1304047

Description

SU-4312 (DMBI) is a selective VEGFR and PDGFR tyrosine kinase inhibitor (IC50 = 0.8 and 19.4 μM, respectively). It has also been shown to protect against MPP⁺-induced neurotoxicity in research models by directly inhibiting neuronal nitric oxide synthase (nNOS), indicating utility in neuroprotection and angiogenesis studies.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number5812-07-7
MW264.32
Purity97.79%
FormulaC17H16N2O
SMILESCN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
TargetPDGFR,VEGFR
SolubilityDMSO:55 mg/mL (208.08 mM)

Bioactivity

Target IC50
VEGFR:0.8 μM|PDGFR:19.4 μM

Storage & Handling

StoragePowder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, NSC 86429, NSC86429, NSC-86429, PDGFR, Platelet-derived growth factor receptor, SU 4312, SU4312, SU-4312, Vascular endothelial growth factor receptor, VEGFR

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Key Properties

No computed properties available.

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SU4312 (orb1304047)

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1 mg
$ 80.00
5 mg
$ 110.00
10 mg
$ 160.00
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