(Z)-SU4312

SKU: orb1301594

Description

(Z)-SU4312 is a small molecule inhibitor exhibiting potent activity against MAO-B (IC50 = 0.2 µM) and weaker inhibition of NOS (IC50 = 19.0 µM). This compound is a useful research tool for studying neurodegenerative pathways and oxidative stress in both cellular and animal models of Parkinson's disease.

Research Area

Cardiovascular Research, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 90828-16-3
• MW: 264.32
• Purity: 99.17% (May vary between batches)
• Formula: C₁₇H₁₆N₂O
• SMILES: C(=C\1/C=2C(NC1=O)=CC=CC2)\C3=CC=C(N(C)C)C=C3
• Target: NOS,MAO,PDGFR,VEGFR
• Solubility: DMSO:30 mg/mL (113.5 mM)

Bioactivity

• Target IC50:
  MAO-B:0.2μM
• In Vivo:
  (Z)-SU4312 was able to selectively inhibit monoamine oxidase-B (MAO-B) activity both in vitro and in vivo, with an IC50 value of 0.2 μM.(Z)-SU43122 provides therapeutic benefits in cellular and animal models of PD, possibly through multiple mechanisms including enhancement of MEF2D through the activation of PI3-K/Akt pathway, maintenance of mitochondrial biogenesis and inhibition of MAO-B activity. (Z)-SU4312 thus may be an effective drug candidate for the prevention or even modification of the pathological processes of PD.
• In Vitro:
  (Z)-SU4312 unexpectedly prevented MPP(+) -induced neuronal apoptosis in vitro and decreased MPTP-induced loss of dopaminergic neurons, reduced expression of mRNA for tyrosine hydroxylase and impaired swimming behaviour in zebrafish. (Z)-SU4312 exhibited non-competitive inhibition of purified neuronal NOS (nNOS) with an IC(50) value of 19.0 μM but showed little or no effects on inducible and endothelial NOS. Molecular docking simulations suggested an interaction between (Z)-SU4312 and the haem group within the active centre of nNOS.
• Animal Research:
  MPP(+) -treated neurons and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated zebrafish were used to study neuroprotection by (Z)-SU4312. NOS activity was assayed in vitro to examine direct interactions between SU4312 and NOS isoforms.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(Z)SU4312, (Z)-SU-4312, (Z) SU4312, NOS, MAO-B, SU 4312, SU4312, SU-4312

Compound Identifiers

PubChem CID

6450842