NSC 86429

SKU: orb1223459

Description

SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.

Key Properties

• CAS Number: 5812-07-7
• MW: 264.33
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₆N₂O
• SMILES: CN(C)C1=CC=C(C=C1)/C=C\2/C3=CC=CC=C3NC2=O
• Target: Akt
• Solubility: In Vitro: DMSO : 50 mg/mL (189.16 mM)

Bioactivity

• In Vitro:
  Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SU-4312 | SU 4312 | SU4312. DMBI | NSC 86429

Quick Database Links

Gene Symbol

Akt