SU16f

SKU: orb1706595

Description

SU16f is a potent and selective PDGFRβ inhibitor (IC50 = 10 nM) that blocks PDGFRβ-mediated signaling. Its application in research includes in vitro studies demonstrating inhibition of gastric cancer cell proliferation and migration driven by MSC-conditioned medium, highlighting its utility in oncology and stromal interaction research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 251356-45-3
• MW: 386.44
• Purity: 98.38% (May vary between batches)
• Formula: C₂₄H₂₂N₂O₃
• SMILES: C(=C1C=2C(=CC(=CC2)C3=CC=CC=C3)NC1=O)C4=C(C)C(CCC(O)=O)=C(C)N4
• Target: PDGFR
• Solubility: DMSO:25 mg/mL (64.69 mM)

Bioactivity

• Target IC50:
  PDGFR1:2.29 μM|PDGFR2:140 nM|PDGFRβ:10 nM
• In Vitro:
  SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM, inhibits GC-MSC-CM-promoted cell proliferation, downregulates p-AKT, Bcl-xl, and Bcl-2 levels, upregulates Bax expression, and modulates E-cadherin, N-cadherin, Vimentin, and α-SMA levels in SGC-7901 cells .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-substituted indolin-2-one 16f, PDGFR1, PDGFR2, PDGFRβ, SU16f, SU-16F, SU 16F

Compound Identifiers

PubChem CID

53396310