SU 5402

SKU: orb1300276

Description

SU 5402

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 215543-92-3
• MW: 296.32
• Purity: 99.08%
• Formula: C₁₇H₁₆N₂O₃
• SMILES: C(=C1C=2C(NC1=O)=CC=CC2)C3=C(CCC(O)=O)C(C)=CN3
• Target: FGFR,VEGFR,PDGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.75 mM);DMSO:29.6 mg/mL (99.89 mM)

Bioactivity

• Target IC50:
  VEGFR2:20 nM|EGFR:30 nM|FGFR1:30 nM|PDGFRβ:510 nM
• In Vivo:
  In mice, SU5416 (25 mg/kg, i.p.) inhibits subcutaneous growth of a panel of tumor cell lines by inhibitin the angiogenic process associated with tumor growth.
• In Vitro:
  SU5402 inhibits VEGF-, FGF-, PDGF- dependent cell proliferation with IC50 of 0.05 μM, 2.80 μM, 28.4 μM, respectively In HUVECs, SU5416 selectively inhibits VEGF-driven mitogenesis in a dose-dependent manner with IC50 of 0.04 μM. In nasopharyngeal epithelial cells, SU5402 attenuates LMP1-mediated aerobic glycolysis, cellular transformation, cell migration, and invasion. In mouse C3H10T1/2 cells, SU 5402 diminishe the effect of FGF23 on cell differentiation.
• Cell Research:
  Tumor cell lines used in the in vitro growth are cultured in media at 37℃n 5–10% CO2. SU5416 is serially diluted in media containing DMSO < .5%) and added to cultures of tumor cells 1 day afte the initiation of culture. Cell growth is measured after 96 h usin the sulforhodamine B method. IC50 are calculated by curve fitting using four-parameter analysis.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, Platelet-derived growth factor receptor, Fibroblast growth factor receptor, FGFR1, FGFR, Inhibitor, SU 5402, SU5402, SU-5402, PDGFR, PDGFRβ, VEGFR, VEGFR2, Vascular endothelial growth factor receptor

Compound Identifiers

PubChem CID

5307