STX-721

SKU: orb3175207

Description

STX-721 is an irreversible EGFR inhibitor targeting the exon 20 insertion (ex20ins) mutation. It specifically inhibits the proliferation of Ba/F3 cells with EGFR exon20 A769_V770 insASV and EGFR exon20 D770_N771 insSVD mutations, demonstrating IC50 values of 5.4 and 5.8 nM, respectively, while showing much less inhibition of cells expressing wild-type EGFR (IC50 = 127.365 nM). Additionally, STX-721, administered at 50 mg/kg once daily, induces tumor regression in a mouse xenograft model utilizing NCI H2073 non-small cell lung cancer (NSCLC) cells with the EGFR exon20 D770_N771 insSVD mutation.

Key Properties

• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Others