STM2120

SKU: orb1944628

Description

STM2120 is a potent small molecule inhibitor targeting the METTL3 methyltransferase, exhibiting an IC50 of 64.5 μM and demonstrating activity against METTL14. It serves as a valuable chemical probe for investigating the role of m6A RNA methylation in cancer biology and other diseases, facilitating both in vitro and in vivo epigenetic research.

Key Properties

• CAS Number: 2762286-04-2
• MW: 333.34
• Purity: 99.56% (May vary between batches)
• Formula: C₁₈H₁₅N₅O₂
• SMILES: O=C1C=C(N=C2C=CC=CN12)C(=O)NCC=3N=C4C=CC=C(N4C3)C
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3 mM);DMSO:3.34 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  STM2120, at concentrations ranging from 0.04 to 50 μM for a duration of 72 hours, exhibits no impact on the proliferation of MOLM-13 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

METTL3

Compound Identifiers

PubChem CID

168355665