STING-IN-17

SKU: orb3173756

Description

STING-IN-17 is an orally active inhibitor of STING (human STING IC50= 29 nM, murine STING IC50= 15 nM). It effectively suppresses the phosphorylation of STING, TBK1, and IRF3. The compound inhibits the expression of IP10, IFNB1, and ISG56 mRNA in a dose-dependent manner. Additionally, STING-IN-17 reduces ROS and inhibits the expression of cleaved-PARP/caspase-3. It shows potential for improving renal function and can be utilized in research on inflammatory diseases such as acute kidney injury.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 3069635-58-8
• MW: 550.56
• Formula: C₃₀H₂₆F₄N₄O₂
• SMILES: O=C(NC1=CNC=2C=CC=CC21)C3=CC=C4C(=C3)N(C(=O)C4(C)C)CC5CN(C6=CC(F)=CC(=C6)C(F)(F)F)C5
• Target: IκB/IKK,ROS,STING,PARP,Caspase,IFNAR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IκB/IKK,ROS,STING,PARP,Caspase,IFNAR