STING-IN-11

SKU: orb2944397

Description

STING-IN-11 (Compound 42) is a potent, orally active small molecule inhibitor of STING palmitoylation (IC₅₀ = 37.8 nM). It effectively suppresses downstream TBK1-IRF3 signaling and the subsequent production of inflammatory cytokines, making it a valuable tool for investigating STING-driven pathologies in both cellular and animal models of autoinflammatory disease.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2925028-15-3
• MW: 403.85
• Purity: 99.84% (May vary between batches)
• Formula: C₂₁H₂₀ClF₂N₃O
• SMILES: O=C(NC1=CC=C(C=C1)C2CCC(F)(F)CC2)NC3=CNC=4C=CC(Cl)=CC43
• Target: STING
• Solubility: DMSO:80.00 mg/mL (198.09 mM)

Bioactivity

• Target IC50:
  STING:37.8 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

173640860