STING agonist-45

SKU: orb3173196

Description

STINGagonist-45 is a selective STING agonist (EC50= 0.28 μM) that activates the innate immune response through the cGAS-STING pathway, increasing key markers such as p-TBK1 and IRF3. This compound exhibits potent STING activation in human peripheral blood mononuclear cells (PBMC), inducing type I interferons like IFN-β and downstream cytokines such as TNF-α and IL-6. In mouse models, STINGagonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8+ T cell infiltration. It is applicable for research on STING-associated diseases.

Key Properties

• CAS Number: 2361424-97-5
• MW: 426.48
• Formula: C₂₁H₂₆N₆O₄
• SMILES: O=C(N)C1=CC=2N=C(NC(=O)C3=CC(=NN3CC)C)N(C2C(OC4COC4)=C1)CCC
• Target: Interleukin,TNF,IFNAR,cGAS,STING

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,TNF,IFNAR,cGAS,STING