STING agonist-4

SKU: orb1309057

Description

STING agonist-4 is a potent small molecule activator of the STING receptor, demonstrating an IC50 of 20 nM. It is widely used in immuno-oncology and antiviral research to stimulate the cGAS-STING pathway in both cellular assays and preclinical animal models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 2138300-40-8
• MW: 678.74
• Purity: 97.28% (May vary between batches)
• Formula: C₃₄H₃₈N₁₂O₄
• SMILES: CCn1nc(C)cc1C(=O)Nc1nc2cc(ccc2n1CCCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(ccc12)C(N)=O)C(N)=O
• Target: STING
• Solubility: DMSO:10 mg/mL (14.73 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• Target IC50:
  STING agonist-4:20 nM
• In Vitro:
  STING agonist-4 (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (0.001 nM-1 μM) inhibits the binding of full-length STING to the solid support (Kd: 1.6 nM). STING agonist-4 (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand)(EC50 of 53.9 μM). STING agonist-4 (3 μM; 4 hours) promotes the production of interferon γ-induced protein 10 (IP-10), IL-6, and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MITA, MPYS, inhibit, ERIS, Inhibitor, STING agonist 4, STING agonist4, STING agonist-4, Stimulator of Interferon Genes, STING, TMEM173

Compound Identifiers

PubChem CID

132000066