STING Agonist 1a

• Catalog Number: orb1692257
• Category: Small Molecules
• Description: STING Agonist 1a
• Purity: 98.00%
• MW: 396.23
• Biological Activity: STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .
• CAS Number: 652142-94-4
• Formula: C₁₉H₁₁Cl₂N₅O
• SMILES: ClC=1C=2N(C(=NN2)C3=CC4=C(N=C3Cl)C=CC(OC)=C4)C=5C(N1)=CC=CC5
• Storage: -20°C
• Note: For research use only