STIM1-TFR1-IN-1

SKU: orb3210846

Description

STIM1-TFR1-IN-1 is an inhibitor of the stromal interaction molecule 1-transferrin receptor 1 (STIM1-TFR1) protein complex, demonstrating a dissociation constant (Kd) of 2.18 μM with STIM1-CD protein. This compound disrupts the interaction between STIM1 and TFR1, thereby reducing TFR1-mediated iron uptake activity. It also inhibits ferroptosis, lipid peroxidation, and the production of reactive oxygen species (ROS), while enhancing the activity of glutathione peroxidase 4 (GPX4) and the glutathione/oxidized glutathione ratio, effectively reversing ferroptosis-associated mitochondrial morphological changes. Additionally, STIM1-TFR1-IN-1 provides neuroprotection and mitigates brain injury, making it a valuable tool for intracerebral hemorrhage research.

Key Properties

• CAS Number: 2196106-61-1
• MW: 319.43
• Formula: C₁₅H₂₁N₅OS
• SMILES: [C@@H](C(NC=1NC(=NN1)C2CCC2)=O)(CCSC)N3C=CC=C3
• Target: ROS,Glutathione Peroxidase,Ferroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,Glutathione Peroxidase,Ferroptosis