STF-62247

SKU: orb1225328

Description

STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells; induces cytotoxicity and reduces tumor growth in VHL-deficient cells in a HIF-independent manner, PI3K and Golgi trafficking are required as initial signals in STF-62247-induced autophagy.Kidney Cancer Preclinical.

Key Properties

• CAS Number: 315702-99-9
• MW: 267.3488
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₃N₃S
• SMILES: CC1=CC(NC2=NC(C3=CC=NC=C3)=CS2)=CC=C1
• Target: Autophagy
• Solubility: DMSO: ≥ 31 mg/mL

Bioactivity

• In Vivo:
  STF-62247 (2.7-8 mg/kg; intraperitoneal injection; daily; for 9 days) treatment significantly reduces tumor growth of VHL-deficient cells. Animal model: SCID mice implanted with SN12C-VHL shRNA cells. Dosage: 2.7 mg/kg, or 8 mg/kg. Administration: Intraperitoneal injection; daily; for 9 days. Result: Significantly reduced tumor growth of VHL-deficient cells.
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• In Vitro:
  In RCC4, RCC4/VHL, SN12C, SN12C-VHL shRNA cells, STF-62247 (0-30 μM) is selectively toxic to VHL-deficient cells compared to their VHL wild-type counterparts. STF-62247-treated cells accumulated intracytoplasmic vacuoles characteristic of cells undergoing autophagy. Moreover, these vacuoles are larger in VHL-deficient RCC4 and SN12C-VHL shRNA cells than in wild-type VHL cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

STF62247 | STF 62247

Quick Database Links

Gene Symbol

Autophagy