StemRegenin 1 (SR1)

SKU: orb1226741

Description

StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.(In Vitro):StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. StemRegenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that StemRegenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, StemRegenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.

Key Properties

• CAS Number: 1227633-49-9
• MW: 429.54
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₃N₅OS
• SMILES: OC1=CC=C(CCNC2=C3N=CN(C(C)C)C3=NC(C4=CSC5=CC=CC=C54)=N2)C=C1
• Target: AhR
• Solubility: DMSO: 86 mg/mL (200.21 mM)

Bioactivity

• In Vitro:
  StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. Stem Regenin 1 inhibits photoaffinity ligand (PAL) binding (IC50 = 40 nM) These results support the conclusion that Stem Regenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, Stem Regenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SR1

Quick Database Links

Gene Symbol

AhR