StemRegenin 1 Hydrochloride

SKU: orb1704030

Description

StemRegenin 1 Hydrochloride is an aryl hydrocarbon receptor (AhR) antagonist (IC50=127 nM) that suppresses RANKL-induced osteoclastogenesis and promotes the expansion of hematopoietic progenitor cells derived from human embryonic stem cells. It is a valuable research tool for studying hematopoiesis, bone biology, and AhR signaling pathways in vitro.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 2319882-01-2
• MW: 466
• Purity: 99.94%
• Formula: C₂₄H₂₄ClN₅OS
• SMILES: Cl.CC(C)n1cnc2c(NCCc3ccc(O)cc3)nc(nc12)-c1csc2ccccc12
• Target: AhR
• Solubility: DMSO:≤ 2.5 mg/mL

Bioactivity

• Target IC50:
  AhR:127 nM
• In Vivo:
  Method: StemRegenin 1 Hydrochloride (30 μg/kg, administered three times per week, every other day, for 30 days) was intraperitoneally injected into mice that had undergone total-body irradiation (TBI) (irradiation dose 6 Gy) 4 hours prior, to investigate the radioprotective effects of StemRegenin 1 Hydrochloride on lethally irradiated mice. Results: StemRegenin 1 Hydrochloride alleviated the lethal effects and pancytopenia induced by total-body irradiation (TBI) in mice .
• In Vitro:
  Culture of mPB CD34+ cells with cytokines plus StemRegenin 1 Hydrochloride for 7 days increased the number of CD34+, CD133+, and CD90+ hematopoietic stem and progenitor cell populations 2.6-, 2.3-, and 10-fold, respectively . StemRegenin 1 Hydrochloride in the absence of cytokines did not induce proliferation, and at concentrations above 1 μM, StemRegenin 1 Hydrochloride treatment is anti-proliferative .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

StemRegenin 1, StemRegenin 1 (hydrochloride), StemRegenin 1 (hydrochloride) (1227633-49-9 free base), 1227633-49-9, 1227633-49-9 free base

Compound Identifiers

PubChem CID

89928937