STAT6-IN-5

SKU: orb2564623

Description

STAT6-IN-5 (Example 84) is a potent STAT6 inhibitor with an IC50 of 0.24 µM. It is a valuable research tool for studying STAT6-dependent pathways in inflammation and allergy, applicable in both in vitro biochemical assays and in vivo models such as atopic dermatitis.

Research Area

Cancer Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3033742-22-9
• MW: 571.57
• Purity: 99.78% (May vary between batches)
• Formula: C₂₆H₂₄F₃N₇O₃S
• SMILES: O=C(NC1=NN=C(S1)C)C2=CC(=CC=3C=C(C4=CC=C(C=C4)N5C(=O)N(N=C5C)C)N(C32)CCOC)C(F)(F)F
• Target: STAT
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (5.77 mM);DMSO:80 mg/mL (139.97 mM)

Bioactivity

• Target IC50:
  STAT6:0.24 μM
• In Vitro:
  At concentrations of 0.1 μM and 1 μM, STAT6-IN-5 achieved inhibition rates of 93% and 100% against STAT6, respectively.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171714310