STAT5-IN-2

SKU: orb1706599

Description

STAT5-IN-2 is a small molecule STAT5 inhibitor demonstrating antileukemic activity, with EC50 values of 9 μM in K562 cells and 5 μM in KU812 cells. It is a research tool for studying STAT5 signaling in hematological cancers, applicable in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2111834-61-6
• MW: 397.51
• Purity: 99.55% (May vary between batches)
• Formula: C₂₆H₂₇N₃O
• SMILES: CC1(C)CCN(CCOc2ccc3[nH]ccc3c2)c2ccc(cc12)-c1cccnc1
• Target: STAT,Apoptosis
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (8.3 mM);DMSO:90 mg/mL (226.41 mM)

Bioactivity

• Target IC50:
  K562 cells:9 μM (EC50)|KU812 cells:5 μM (EC50)
• In Vitro:
  STAT5-IN-2 (100 nM-50 µM) inhibits cell growth in KG1a and MV-4-11 cell lines with EC50 values of 2.6 µM and 3.5 µM, respectively. In K562, KU812, KG1a and MV-4-11 cells, STAT5-IN-2 (10 µM) induces apoptosis. In KG1a, MV-4-11 and KU812 cells, STAT5-IN-2 (10 µM) blocks the phosphorylation of STAT5.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KU812 cells, K562 cells, Apoptosis, STAT5, STAT5 IN 2, STAT5IN2, STAT-5-IN-2, STAT5-IN-2

Compound Identifiers

PubChem CID

137628635