STAT3/CAIX-IN-1

SKU: orb3135181

Description

STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (Kd: 60.03 μM) and CAIX (IC50: 80.45 nM). It induces ferroptosis by elevating reactive oxygen species (ROS) and lipid peroxides. This compound also inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 is applicable for research in triple-negative breast cancer (TNBC).

Research Area

Cancer Biology, Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3053583-60-8
• MW: 687.63
• Formula: C₂₈H₂₃F₆N₅O₅S₂
• SMILES: C(=C\1/C(=O)\C(=C\C2=CC=C(C(F)(F)F)C=C2)\CN(C(CCCC(NC=3SC(S(N)(=O)=O)=NN3)=O)=O)C1)\C4=CC=C(C(F)(F)F)C=C4
• Target: Caspase,STAT,ROS,Carbonic Anhydrase,Ferroptosis,Bcl-2 Family,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,STAT,ROS,Carbonic Anhydrase,Ferroptosis,Bcl-2 Family,Apoptosis