STAT3-IN-53

SKU: orb3210485

Description

STAT3-IN-53 (Compound L20) is a STAT3 inhibitor with a dissociation constant (Kd) of 6.16 μM. It binds directly to the SH2 domain of STAT3, inhibiting phosphorylation at the Y705 site without affecting total STAT3 protein levels. STAT3-IN-53 downregulates the transcription and expression of cyclin-D1 and c-Myc, induces cell cycle arrest, and promotes apoptosis. Additionally, STAT3-IN-53 exhibits anticancer activity against colorectal cancer.

Key Properties

• CAS Number: 3113051-34-3
• MW: 678.73
• Formula: C₃₃H₃₃F₃N₈O₃S
• SMILES: O=C(OCC)C1=NC=CC(=C1)C2=NN=C(S2)NC3=CC=4N=C(C=5C=CC(OC(F)(F)F)=CC5)N(C4C=C3N6CCN(CC)CC6)C7CC7
• Target: STAT,c-Myc,CDK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

STAT,c-Myc,CDK,Apoptosis