STAT3-IN-38

• Catalog Number: orb2814277
• Category: Small Molecules
• Description: STAT3-IN-38 (Compound 4m) is a STAT3 inhibitor with a dissociation constant (K_D) of 45.33 µM for rhSTAT3, and is a derivative of Celastrol. It binds to the SH2 domain of the STAT3 protein, inhibiting phosphorylation at the pTyr705 site and suppressing downstream gene expression of Survivin and Mcl-1. STAT3-IN-38 can arrest the cell cycle and induce apoptosis in colorectal cancer cells.
• CAS Number: 3033049-16-7
• MW: 559.8
• SMILES: C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(NCCC4=CC=CS4)=O)(C)C3)[H])CC[C@]5(C)C2=CC=C6C5=CC(=O)C(O)=C6C
• Formula: C₃₅H₄₅NO₃S
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.