STAT3-IN-27

SKU: orb3134324

Description

STAT3-IN-27 (Compound 41) is an orally active STAT3 inhibitor that impedes STAT3 phosphorylation with a KD of 4.4 μM and suppresses STAT3 transcriptional activity with an IC50 of 22.57 nM. It inhibits the proliferation of various cancer cells with an IC50 ranging from 10 to 500 nM. STAT3-IN-27 causes cell cycle arrest at the G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116 cells, and inhibits HCT116 cell migration. It exhibits antitumor effects in mouse models.

Research Area

Cancer Biology, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• Formula: C₁₈H₂₁N₃O₄S
• Target: Apoptosis,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,STAT