STAT3-IN-13

SKU: orb1687553

Description

STAT3-IN-13 is a potent, selective STAT3 inhibitor that binds the SH2 domain to block Y705 phosphorylation, inducing apoptosis and suppressing proliferation. It demonstrates anticancer activity in vitro and in vivo, making it a valuable research tool for studying breast and hepatocellular carcinoma.

Research Area

Cancer Biology, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2248552-86-3
• MW: 436.49
• Purity: 99.88% (May vary between batches)
• Formula: C₂₁H₂₀N₆O₃S
• SMILES: C(#N)C=1C2=C(SC1NC(=O)C=3C=NN(C)C3)CN(C(NC4=CC=C(OC)C=C4)=O)CC2
• Target: Bcl-2 Family,Apoptosis,STAT
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.46 mM);DMSO:80 mg/mL (183.28 mM)

Bioactivity

• Target IC50:
  143B cells:0.25 μM|STAT3:0.96 μM (Kd)|HOS cells:0.11 μM|MG-63 cells:0.55 μM
• In Vivo:
  In vivo, STAT3-IN-13 (compound 6f), administered intraperitoneally at doses of 10-20 mg/kg twice daily for 4 weeks in nude mice, effectively blocks osteosarcoma growth and metastasis .
  Read more...
• In Vitro:
  STAT3-IN-13 (compound 6f), over a period of 48 hours, demonstrates anti-proliferative activity with IC50 values of 0.25, 0.11, and 0.55 μM for 143B, HOS, and MG63 cells, respectively .In the concentration range of 0.001-100 μM, STAT3-IN-13 (compound 6f) binds to STAT3 and interacts with STAT3^586-685 in a concentration-dependent manner, with a KD of 0.96 μM .Over a period of 24 hours at concentrations ranging from 0 to 1.0 μM in 143B and HOS cells, STAT3-IN-13 (compound 6f) inhibits STAT3 Y705 phosphorylation and suppresses STAT3 in tumor cells .At concentrations ranging from 0 to 1.0 μM over 48 hours in 143B cells, STAT3-IN-13 (compound 6f) induces apoptosis in a dose-dependent manner .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

STAT3

Compound Identifiers

PubChem CID

163358781