STAT3-IN-11

SKU: orb1689007

Description

STAT3-IN-11 is a selective small molecule inhibitor that targets STAT3 by suppressing its phosphorylation at Tyr705 and downstream Survivin phosphorylation. This action induces apoptosis in cancer cells, supporting its investigation as a potential therapeutic agent in oncology research, including in vitro cell-based studies and in vivo tumor models.

Research Area

Cancer Biology, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2503096-50-0
• MW: 335.35
• Purity: 98.30% (May vary between batches)
• Formula: C₂₀H₁₇NO₄
• SMILES: CC1=C(CCNC(=O)c2ccccc2)C(=O)c2c(O)cccc2C1=O
• Target: Apoptosis,STAT
• Solubility: DMSO:80 mg/mL (238.56 mM)

Bioactivity

• In Vitro:
  STAT3-IN-11 (2.5-10μM, 6 hours) dose-dependently inhibits phosphorylation of STAT3 at the pTyr705 site stimulated by IL-6 in MDA-MB-231 cells. However, it does not affect the phosphorylation of upstream kinases such as p-JAK2 and p-Src, nor the phosphorylation of STAT1, a STAT subtype.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, STAT3

Compound Identifiers

PubChem CID

164517204