Ζ-Stat

SKU: orb1304087

Description

ζ-Stat (NSC37044) is a selective PKC-ζ inhibitor (IC50=5 µM) with demonstrated antitumor activity in vitro, suppressing proliferation and promoting apoptosis in melanoma models. Its research applications include studying PKC-ζ signaling in cancer biology and exploring potential therapeutic strategies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3316-02-7
• MW: 384.36
• Purity: 99.85% (May vary between batches)
• Formula: C₁₀H₈O₁₀S₃
• SMILES: Oc1cc(cc2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
• Target: PKC,Apoptosis
• Solubility: H2O:62.5 mg/mL (162.61 mM)

Bioactivity

• Target IC50:
  PKCζ:5 μM
• In Vitro:
  Ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-Ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level.Ζ-Stat (0.1-10 μM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations.Ζ-Stat (7 or 10 μM; 24-72h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%.Ζ-Stat (5 μM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells.Ζ-Stat (5 μM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, antitumor, atypical, NSC37044, NSC-37044, NSC 37044, kinase, inhibit, Inhibitor, melanoma, Protein kinase C, protein, PKC-ζ, PKCζ, PKC, Ζ Stat, ΖStat, ζ-Stat, Ζ-Stat

Compound Identifiers

PubChem CID

76828