Stafib-2

SKU: orb1744032

Description

Stafib-2 is a cell-impermeable small molecule that potently and selectively inhibits STAT5b (IC50 = 82 nM) over STAT5a (IC50 = 1.7 µM). This inhibitor is a valuable research tool for studying STAT5b-dependent signaling pathways in biochemical and cell-free assays.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2097938-74-2
• MW: 644.46
• Purity: 98.97% (May vary between batches)
• Formula: C₂₈H₂₆N₂O₁₂P₂
• SMILES: O(P(=O)(O)O)C1=C(OP(=O)(O)O)C=CC(CNC(COC2=CC=C(C(NC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2)=O)=C1
• Target: STAT
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.1 mM);DMSO:45 mg/mL (69.83 mM)

Bioactivity

• Target IC50:
  STAT5b:82 nM|STAT5b:9 nM(Ki)|STAT5a:1.7 μM
• In Vitro:
  Stafib-2 (3-10 μM; 4-48 h) does not show significant activity in K562 and MDA-MB-231 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Stafib 2, Stafib2, Stafib-2, STAT5

Compound Identifiers

PubChem CID

129896883