Stafib-1

SKU: orb1702765

Description

Stafib-1 is a potent and selective STAT5β inhibitor that targets its SH2 domain, exhibiting an IC50 of 154 nM and a Ki of 44 nM. This small molecule is a valuable research tool for studying STAT5β-dependent signaling in cancer and hematopoiesis, with utility in both in vitro and in vivo experimental models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1688703-26-5
• MW: 602.42
• Purity: 97.18% (May vary between batches)
• Formula: C₂₆H₂₄N₂O₁₁P₂
• SMILES: O(P(=O)(O)O)C1=C(OP(=O)(O)O)C=CC(CNC(COC2=CC3=C(C=C2)C=C(C(NC4=CC=CC=C4)=O)C=C3)=O)=C1
• Target: STAT
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.48 mM);DMSO:95 mg/mL (157.7 mM)

Bioactivity

• Target IC50:
  STAT5b:154 nM (IC50)
• In Vitro:
  Stafib-1 inhibits STAT5β with more than 50-fold selectivity over STAT5a.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, K562, STAT5β, STAT5b, Stafib 1, Stafib1, Stafib-1, STAT

Compound Identifiers

PubChem CID

122432036