Stafia-1

SKU: orb1298172

Description

Stafia-1 is a selective small-molecule inhibitor of STAT5a with an IC50 of 22.2 µM, exhibiting high specificity over STAT5b and other STAT proteins. It is a valuable research tool for studying STAT5a-dependent signaling in leukemia and other cancers, applicable in both in vitro and in vivo experimental models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2582757-90-0
• MW: 506.44
• Purity: 98.15% (May vary between batches)
• Formula: C₂₄H₂₇O₁₀P
• SMILES: O(P(=O)(O)O)C1=CC(=CC(=C1)C2=CC(OC)=C(OC)C(OC)=C2)C3=CC(OC)=C(OC)C(OC)=C3
• Target: STAT
• Solubility: DMSO:50 mg/mL (98.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.95 mM)

Bioactivity

• Target IC50:
  STAT5a:22.2 μM|STAT5a:10.9 μM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

domain, cells, inhibit, Inhibitor, leukemia, STAT5a, Stafia 1, Stafia1, Stafia-1, STAT, selectivity, SH2

Compound Identifiers

PubChem CID

146681206