ST1936

SKU: orb1704034

Description

ST1936 oxalate is a potent and selective agonist of the human 5-HT6 receptor, which upon full activation stimulates downstream cAMP, Ca2+, ERK1/2, and Fyn kinase signaling. This compound also exhibits inhibitory activity at 5-HT7 and 5-HT2B receptors. It is a valuable research tool for investigating serotonin receptor function in both in vitro and in vivo models of CNS disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1210-81-7
• MW: 236.74
• Purity: 98.00% (May vary between batches)
• Formula: C₁₃H₁₇ClN₂
• SMILES: CN(C)CCc1c(C)[nH]c2ccc(Cl)cc12
• Target: 5-HT Receptor,Adrenergic Receptor
• Solubility: DMSO:80 mg/mL (337.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (13.94 mM)

Bioactivity

• Target IC50:
  α2-adrenoceptor (rat):300 nM (Ki)|α1-adrenoceptor (rat):390 nM (Ki)|5-HT6 receptor:13 nM (Ki)|α2-adrenoceptor (human):300 nM (Ki)|5-HT7 receptor:168 nM (Ki)|5-HT2B receptor:245 nM (Ki)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ST 1936, ST 1936 oxalate, ST1936, ST-1936, ST1936 Oxalate, ST-1936 Oxalate, 5HT Receptor, 5-HT2B, 5HTReceptor, 5-HT7, 5-HT6

Compound Identifiers

PubChem CID

9921064