ST13

SKU: orb3174181

Description

ST13 is an ortho-hydroxyaniline compound that functions as a selective, slow-binding inhibitor of HDAC1 and HDAC2, exhibiting IC50 values of 23 nM and 49 nM, respectively. It shows relatively weaker inhibition for HDAC3 (IC50= 4.30 μM) and HDAC6 (IC50 > 10 μM). The mechanism of induced binding by ST13 occurs through a two-step process: initially, a rapid formation of the collision complex (EI) between the enzyme and inhibitor occurs, followed by a gradual conversion to a stable complex (E*I). Additionally, ST13 can induce apoptosis in cancer cells and is applicable in research involving melanoma and triple-negative breast cancer.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1013620-98-8
• MW: 346.39
• Formula: C₂₁H₁₈N₂O₃
• SMILES: O=C(NC=1C=C(C=CC1O)C=2C=CC=CC2)C3=CC=C(C=C3)NC(=O)C
• Target: Apoptosis,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,HDAC