st-Ht31

• Catalog Number: orb1140638
• Category: Proteins
• Description: AKAP-PKA interaction inhibitor; Cell penetrating peptides.
• CAS Number: 188425-80-1
• Modifications: N-terminal stearyl.
• Structure: Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH
• Target Areas: Protein-protein interactions, Kinases
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2798.27 Da
• Formula: C₁₂₉H₂₁₇N₂₉O₃₉
• Solubility (25°C): Soluble to 1 mg/ml in 0.01M PBS
• Protein Sequence: Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH
• Storage: Store dry, frozen and in the dark
• Alternative names: 188425-80-1, DLIEEAASRIVDAVIEQVKAAGAY , KS 200KS20
• Background: st-Ht31 is a stearated and cell permeable version of the peptide Ht-31, which inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP). The sequence of st-Ht31 is derived from human thyroid RII anchoring protein Ht31, comprising residues 493-515, and is the minimum region of Ht 31 required for RII binding. Disruption of the AKAP-PKA interaction by st-Ht31 alters human airway smooth muscle proliferation and enhances contractile force generation with upregulation of the contractile protein α-sm-actin. st-Ht31 also increases cytosolic PKA activity and is able to reverse foam cell formation and restore metabolic health in otherwise dysfunctional macrophages.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.