ST-193

SKU: orb1309062

Description

ST-193 is a highly potent small-molecule inhibitor effective against multiple pathogenic arenaviruses, including Guanarito, Junin, Lassa, and Machupo viruses, with IC50 values in the low nanomolar range. This compound is a valuable research tool for studying arenavirus entry and replication in vitro and shows promise for further development of antiviral therapeutics.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 489416-12-8
• MW: 371.47
• Purity: 99.67% (May vary between batches)
• Formula: C₂₄H₂₅N₃O
• SMILES: COc1ccc(cc1)-n1cnc2cc(NCc3ccc(cc3)C(C)C)ccc12
• Target: Anti-infection,Virus Protease
• Solubility: DMSO:150 mg/mL (403.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.77 mM)

Bioactivity

• Target IC50:
  Guanarito:0.44 nM |Lassa:1.4 nM |Machupo:3.1 nM |Junin:0.62 nM
• In Vivo:
  ST-193, exhibits submicromolar antiviral activity in vitro. To determine the antiviral utility of ST-193 in vivo, Tested the efficacy of this compound in the LASV guinea pig model. Four groups of strain 13 guinea pigs were administered 25 or 80 mg/kg ST-193, 25 mg/kg of ribavirin, or the vehicle by the intraperitoneal (i.p.) route before infection with a lethal dose of LASV, strain Josiah, and continuing once daily for 14 days. Control animals exhibited severe disease, becoming moribund between days 10 and 15 postinfection. ST-193-treated animals exhibited fewer signs of disease and enhanced survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups were elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediated a 2-3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs was 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups. These data suggest that ST-193 may serve as an improved candidate for the treatment of Lassa fever.
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• In Vitro:
  LASV pseudotypes(IC50 of 1.6 nM)inhibited by ST-193 . ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC50s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ST 193, ST193, ST-193, Virus Protease, VirusProtease, Arenavirus, Guanarito, Lassa, Inhibitor, Machupo, inhibit, Junin

Compound Identifiers

PubChem CID

3697969