ST-1006

SKU: orb1695159

Description

ST-1006 is a potent and selective histamine H4 receptor agonist (pKi: 7.94) with demonstrated anti-inflammatory and anti-pruritic properties. It effectively induces basophil migration in vitro and has shown relevant activity in preclinical models of inflammation and itch.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1196994-11-2
• MW: 367.28
• Purity: 99.98%
• Formula: C₁₆H₂₀Cl₂N₆
• SMILES: N(CC1=C(Cl)C=CC=C1Cl)C2=CC(N3CCN(C)CC3)=NC(N)=N2
• Target: Histamine Receptor
• Solubility: DMSO:3.68 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  H4 receptor:7.94(pKi )
• In Vivo:
  ST-1006 (1-100 mg/kg; s.c.; male CD-1 mice) demonstrates anti-inflammatory and anti-itch properties .
• In Vitro:
  ST-1006 (10 μM) effectively induces eosinophil migration and, at concentrations ranging from 0-100 μM, inhibits FceRI-mediated eosinophil activation, reducing CD63 and CD203c expression in activated eosinophils through FceRI activation .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

H4 receptor, Histamine Receptor, HistamineReceptor, ST1006, ST-1006, ST 1006

Compound Identifiers

PubChem CID

45257132