(S,S,S)-AHPC hydrochloride

SKU: orb1218453

Description

(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the recruitment of the VHL protein.

Key Properties

• CAS Number: 2115897-23-7
• MW: 467.02
• Purity: >98% (HPLC)
• Formula: C₂₂H₃₁ClN₄O₃S
• SMILES: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@@H](O)C3.[H]Cl
• Target: E3 Ligase Ligand
• Solubility: H2O: 99 mg/mL (211.98 mM; Need ultrasonic); DMSO: 60 mg/mL (128.47 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S,S,S)-VH032-NH2 hydrochloride

Quick Database Links

Gene Symbol

E3 Ligase Ligand