SSK1

SKU: orb1692874

Description

SSK1

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2629250-69-5
• MW: 788.61
• Purity: 99.83% (May vary between batches)
• Formula: C₃₁H₃₄F₂N₄O₁₈
• SMILES: [H][C@]1(O[C@H](CO)[C@@H](O)C1(F)F)n1ccc(NC(=O)OCc2ccc(O[C@@H]3O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)c(c2)[N+]([O-])=O)nc1=O
• Target: Apoptosis,p38 MAPK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.34 mM);DMSO:245 mg/mL (310.67 mM)

Bioactivity

• In Vivo:
  Lung-injured mice (3-6 months old) received intratracheal administration of bleomycin (1.5 mg/kg) and were subjected to intraperitoneal injection of SSK1 (0.5 mg/kg) or vehicle (DMSO) for two consecutive days each week for 4 weeks. The results indicate that SSK1 can eliminate SA-β-gal-positive senescent cells and reduce aging-related markers in vivo.
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• In Vitro:
  SSK1 (0.5 μM; 12-72 h) is activated by lysosomal β-galactosidase, selectively kills senescent cells by activating p38 MAPK, and inducing apoptosis.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p38 MAPK, p38MAPK, SSK 1, SSK1, SSK-1

Compound Identifiers

PubChem CID

162642741