SSE15206

SKU: orb1220777

Description

SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.

Key Properties

• CAS Number: 1370046-40-4
• MW: 371.45
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁N₃O₃S?
• SMILES: COc1cc(cc(OC)c1OC)C1CC(=NN1C(N)=S)c1ccccc1
• Target: Microtubule/Tubulin
• Solubility: DMSO:150 mg/mL (403.82 mM)

Bioactivity

• In Vitro:
  SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 x and 10 x GI50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines. Western blot analysis. Cell line: Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells. Concentration: 5 x and 10 x GI50 values (GI50 = 197 nM in HCT-116 cells). Incubation time: 24 hours. Result: Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Microtubule/Tubulin