(S,S)-Secoisolariciresinol diglucoside

SKU: orb1681310

Description

(S,S)-Secoisolariciresinol diglucoside ((S,S)-SDG) is a flaxseed-derived lignan exhibiting anti-inflammatory, antioxidant, and neuroprotective properties. It is utilized in research models for studying metabolic and inflammatory diseases, including obesity and osteoporosis, with applications in both in vitro and in vivo experimental systems.

Research Area

Metabolism Research

Key Properties

• CAS Number: 257930-74-8
• MW: 686.7
• Purity: 99.33% (May vary between batches)
• Formula: C₃₂H₄₆O₁₆
• SMILES: [C@@H]([C@H](CC1=CC(OC)=C(O)C=C1)CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)(CC3=CC(OC)=C(O)C=C3)CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O
• Target: Antioxidant
• Solubility: H2O:80 mg/mL (116.5 mM)

Bioactivity

• In Vivo:
  Secoisolariciresinol diglucoside (oral administration; 4 mg/mouse) administered to 10-week-old male mice 2 hours before the administration of tumor necrosis factor alpha (TNFα) significantly reduced the adhesion of leukocytes to the endothelium by 50% and the migration of leukocytes across the blood-brain barrier by 64%.
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• In Vitro:
  Secoisolariciresinol diglucoside is a major lignan component in flaxseed and exhibits potent antioxidant activity in vitro, acting as an effective scavenger of free hydroxyl radicals.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antioxidant, (S,S)-SDG, (S,S)-Secoisolariciresinol diglucoside, SDG, Secoisolariciresinol diglucoside

Compound Identifiers

PubChem CID

72189390