SRX3207

SKU: orb1704788

Description

SRX3207 is a dual inhibitor targeting Syk and PI3K kinases. It has been utilized in research to investigate mechanisms of tumor immunosuppression, showing activity in both cellular assays and in vivo models for oncology and immunology studies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2254693-15-5
• MW: 555.65
• Purity: 99.85% (May vary between batches)
• Formula: C₂₉H₂₉N₇O₃S
• SMILES: Cc1nn(cc1CN1CCC1)-c1ccnc(Nc2ccc(cc2)-c2csc3c2oc(cc3=O)N2CCOCC2)n1
• Target: PI3K,Syk
• Solubility: DMSO:4.5 mg/mL (8.1 mM)

Bioactivity

• Target IC50:
  ZAP70:1300 nM (IC50)|PI3Kδ:1280 nM (IC50)|Syk:10.7 nM (IC50)|PI3Kγ:11100 nM (IC50)|PI3Kα:861 nM (IC50)
• In Vivo:
  Oral administration of SRX3207 increases antitumor immune response. SRX3207 blocks immunosuppressive MΦ polarization, blocks tumor growth, and increases survival effectively.
• In Vitro:
  The IC50 values are 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 (10 μmol/L) blocks p-AKT.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3K, Syk, SRX 3207, SRX3207, SRX-3207

Compound Identifiers

PubChem CID

137357450