SRT 2183

SKU: orb1307726

Description

SRT 2183 is a potent and selective small molecule activator of Sirtuin-1 (SIRT1), exhibiting an EC1.5 of 0.36 µM. It is widely used in biochemical and cellular research to study SIRT1's role in aging, metabolism, and neurodegenerative diseases, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1001908-89-9
• MW: 468.57
• Purity: >99.99% (May vary between batches)
• Formula: C₂₇H₂₄N₄O₂S
• SMILES: O[C@@H]1CCN(Cc2csc3nc(cn23)-c2ccccc2NC(=O)c2ccc3ccccc3c2)C1
• Target: Apoptosis,Sirtuin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.67 mM);DMSO:240 mg/mL (512.2 mM)

Bioactivity

• Target IC50:
  SIRT1:0.36 μM (EC1.5)
• In Vitro:
  SRT2183 leads to increased mRNA levels of pro-apoptosis and DNA-damage-response genes, accompanied by accumulation of phospho-H2A.X levels. Combination of SRT2183 with panobinostat enhanced the anti-growth and anti-survival effects mediated by either compound alone. Quantitative-PCR confirmed that the panobinostat in combination with SRT2183, SRT501 or resveratrol leads to greater upregulation of GADD45G than any of the single agents. Panobinostat plus SRT2183 in combination showed greater inhibition of c-Myc protein levels and phosphorylation of H2A.X, and increased acetylation of p53. Furthermore, EMSA revealed that NF-κB binds directly to the GADD45G promoter, while STAT3 binds indirectly in complexes with NF-κB. In addition, the binding of NF-κB/STAT3 complexes to the GADD45G promoter is inhibited following panobinostat, SRT501 or resveratrol treatment. Moreover, the combination of panobinostat with SRT2183, SRT501 or resveratrol induces a greater binding repression than either agent alone.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Apoptosis, SIRT1, Sirtuin, SRT2183, SRT-2183, SRT 2183

Compound Identifiers

PubChem CID

24180126