SRT 2104

SKU: orb1300562

Description

SRT 2104 (GSK2245840) is a brain-penetrant small molecule activator selectively targeting SIRT1. It is utilized in research exploring aging, neurodegeneration, and metabolic disorders, with applications in both cellular assays and animal models to study sirtuin-mediated pathways.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1093403-33-8
• MW: 516.64
• Purity: 99.83%
• Formula: C₂₆H₂₄N₆O₂S₂
• SMILES: Cc1nc(sc1C(=O)Nc1ccccc1-c1cn2c(CN3CCOCC3)csc2n1)-c1cccnc1
• Target: Sirtuin
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:3.79 mg/mL (7.34 mM)

Bioactivity

• In Vivo:
  In male C57BL/6J mice, SRT2104 (100 mg/kg, p.o.) extends both mean and maximal lifespan of mice fed a standard diet, and enhances motor coordination, bone mineral density, and insulin sensitivity and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.
• In Vitro:
  SRT2104 reduces p65/RelA acetylation levels in C2C12 cells.
• Cell Research:
  Cells are cultured in low glucose Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% fetal bovine serum and penicillin–streptomycin. Cells are treated with vehicle (0.1% DMSO) or 3 μM SRT2104 for 24 h and then harvested for protein and Western blotting.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SRT2104, SRT-2104, SRT 2104, SIRT1, Sirtuin, sirtuin modulator, GSK2245840, GSK-2245840, GSK 2245840, Inhibitor, inhibit

Compound Identifiers

PubChem CID

25108829